THIS PRODUCT IS FOR RESEARCH PURPOSES ONLY.

+ Description

PEG-MGF (Pegylated Mechano Growth Factor) has been used by bodybuilders and athletes for a few years already. After resistance exercise, IGF-1 is released within the muscle.

Specifically, at this time, immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes. It differs from “regular” IGF-1 mainly due to it’s C-Terminal sequence.

PEG-MGF is a sterile, non-pyrogenic, white lyophilised powder intended for subcutaneous or intramuscular injection, after reconstitution with sterile Water for Injection (0,3% m-Cresol).

+ Mechanism of action

When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1).

This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fibre and tissue. The appearance of PEG-MGF also initiates the up regulation of new protein synthesis. After this initial splicing of IGF-1 into PEG-MGF, production then switches towards producing a systemic release of IGF-1 from the liver, which also up regulates protein synthesis as well.

The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary anabolic mechanism by which the body produces new muscle. PEG-MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.

• Improved skeletal muscle regeneration
• Improved bone density
• More efficient recovery from injury

+ Adverse reaction

The negative side effect that has been primarily linked to Mechano Growth Factor is that of hypoglycemia. This condition, commonly referred to as “low blood sugar,” is thought to be a potential condition relating to the increased efficiency of cellular functionality that the peptide stimulates. Scientific research based on animal test subjects has also concluded that this negative side effect could be countered with an increase intake of glucose for an animal test subject.

Other potential negative side effects that have been linked to the peptide through scientific study of animal test subjects include a drop in blood pressure, swelling of extremities, and increased cardiovascular irregularities up to and including cardiac arrest. That said, scientific study has derived that the potential negative side effects are less likely to occur than the theoretical positive benefits.

+ Instructions for reconstitution

The injection is given into the sub-cutaneous layer which includes adipose tissue (fat).

If you are using insulin syringes which have short needles, you will need to enter the skin at 90°. to the skin, otherwise you can inject as shown in the illustration above with a 29 or 30 gauge, 0.5" needle.

+ Dosage

Recommended dosage of PEG-MGF: 200-400 mcg multiple times per week.

+ Storage

• This product can be used not more than 3 years from the production date (see box).
• After reconstitution, may be stored for a maximum of 14 days in a refrigerator at 2°C – 8°C.
• Store vials in an upright position.
• Store in a refrigerator (2°C – 8°C). Keep in the outer carton in order to protect from light.
• For one month can be stored at room temperature.