TB-500 by Hilma Biocare is a synthetic fraction of the protein thymosin beta-4, which is present in virtually all human and animal cells. The main purpose of this peptide is to promote healing. It also promotes creation of new blood and muscle cells.

The healing effects of TB-500 have been observed in tendons, ligaments, muscle, skin, heart, and the eyes. Thymosin beta-4 is naturally produced in higher concentration where tissue has been damaged. This peptide is also a very potent anti-inflamatory agent.

TB-500 is different from other repair factors (growth hormone, IGF-1), because it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight. Because of this it can travel long distances through the tissues in the human body. One of TB-500 key mechanisms of action is its ability to regulate the cell-building protein − Actin. Of the thousands of proteins present within human cells, actin represents roughly 10% of the total. It is thus a vital component of cell structure and movement.

Thymosin Beta-4 is a protein which consists of 43 amino acids and is encoded by the gene TMSB4X in the human body. It has been studies in numerous clinical trials. Research has shown that if the thymosin beta-4 peptide is used after a heart attack it can reactivate cardiac progenitor cells to repair damaged heart tissue.

Thymosin beta-4 has a very large molecule. In fact, it is so large that it cannot fit entirely into the receptor. Different sections of the molecule have different activities. TB-500 is the part of thymosin beta-4 hormone which promotes the most useful effects (overall healing, repair, new blood and muscle cells). For medical applications it is more practical to use the TB-500 instead of the entire Thymosin Beta-4 protein.

Beeing used in veterinary and human medicine, the TB-500 shows the following effects:

■ Accelerates the recovery of muscles (including the heart muscle), ligaments, joints and skin. It has a pronounced reparative potential on many tissues.

■ Anti-inflammatory effect.

■ Angiogenesis: the growth of new vessels in the muscles, which improves their nutrition.

■ Protects and restores the nervous system.

■ Stimulates the secretion of luteinizing hormone, and as a result of testosterone.

■ Increases tissue sensitivity to the anabolic hormone insulin.

■ Increases joint mobility and ligament distensibility.

■ TB-500 is a cardioprotector that reduces the risk of myocardial infarction, restores myocardium. It has a regenerative property even with myocardial ischemia.